Methods for isolating crystalline form i of 5-azacytidine
AssigneePharmion LLC
InventorsDumitru IONESCU, Peter Blumbergs, Gary L. Silvey
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Abstract
The invention includes methods for isolating crystalline Form I of 5-azacytidine substantially free of other forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising Form I of 5-azacytidine.
Claims4
1-36. (canceled)
A method for isolating crystalline Form I of 5-azacytidine substantially free of other forms, the method comprising:
- recrystallizing 5-azacytidine from a solvent mixture comprising dimethylsulfoxide and isopropyl alcohol;
- and
- isolating the recrystallized 5-azacytidine.
A method for isolating crystalline Form I of 5-azacytidine substantially free of other forms, the method comprising:
- recrystallizing 5-azacytidine from a solvent mixture comprising dimethylsulfoxide and 1-propanol;
- and
- isolating the recrystallized 5-azacytidine.
A method for isolating crystalline Form I of 5-azacytidine substantially free of other forms, the method comprising:
- recrystallizing 5-azacytidine from a solvent mixture comprising dimethylsulfoxide and methanol by seeding said solvent mixture with Form I of 5-azacytidine;
- and isolating the recrystallized 5-azacytidine.
Dependencies are inferred from the claim text.