Orally disintegrating tablet
AssigneeKyowa Hakko Kirin Co., Ltd.
InventorsTakafumi Sato, Motohiro Ota, Makoto Kigoshi, Hideki Morita
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Abstract
It is an object of the present invention to provide an orally disintegrating tablet that has desirable oral disintegrability and excellent tablet hardness, a process for producing the same, and the like. The present invention provides an orally disintegrating tablet comprising: at least one diluent selected from D-mannitol, lactose, trehalose, xylitol, maltitol, and erythritol; a drug; a disintegrant; and at least one binder selected form methacrylic acid copolymer S, methacrylic acid copolymer L, methacrylic acid-ethyl acrylate copolymer, ethyl acrylate-methyl methacrylate copolymer, and methyl methacrylate-butyl methacrylate-dimethylaminoethyl methacrylate copolymer.
Claims14
An orally disintegrating tablet comprising:
- at least one diluent selected from D-mannitol, lactose, trehalose, xylitol, maltitol, and erythritol;
- a drug;
- a disintegrant;
- and
- at least one binder selected form methacrylic acid copolymer S, methacrylic acid copolymer L, methacrylic acid-ethyl acrylate copolymer, ethyl acrylate-methyl methacrylate copolymer, and methyl methacrylate-butyl methacrylate-dimethylaminoethyl methacrylate copolymer.
A process for producing an orally disintegrating tablet that contains at least one diluent selected from D-mannitol, lactose, trehalose, xylitol, maltitol, and erythritol;
- a drug;
- and a disintegrant,
- the process comprising steps of:
- adding a binder liquid to the diluent and performing wet granulation, the binder liquid containing at least one binder selected from methacrylic acid copolymer S, methacrylic acid copolymer L, methacrylic acid-ethyl acrylate copolymer, ethyl acrylate-methyl methacrylate copolymer, and methyl methacrylate-butyl methacrylate-dimethylaminoethyl methacrylate copolymer;
- and
- tableting the granulated material.
Dependencies are inferred from the claim text.