Topical localized isoxazoline formulation comprising glycofurol

A topical localized formulation for the treatment or prophylaxis of parasite infestation in animals which comprises an effective amount of at least one isoxazoline compound of the Formula (I)

• , wherein
• R1=halogen, CF3, OCF3, CN,
• n=integer from 0 to 3, preferably 1, 2 or 3,
• R2=C1-C3-haloalkyl, preferably CF3 or CF2Cl
• T=5- or 6-membered ring, which is optionally substituted by one or more radicals Y,
• Y=methyl, halomethyl, halogen, CN, NO2, C(S)NH2, or two adjacent radicals Y form together a chain CH—CH═CH—CH, N—CH═CH—CH, CH—N═CH—CH, CH—CH═N—CH, or CH—CH═CH—N, HC═HC—CH, CH—CH═CH, CH═CH—N, N—CH═CH
• Q=X—NR3R4 or a 5-membered N-heteroaryl ring, which is optionally substituted by one or more radicals ZA, ZB ZD;
• X=CH2, CH(CH3), CH(CN), CO, CS,
• R3=hydrogen, methyl, haloethyl, halopropyl, halobutyl, methoxymethyl, methoxyethyl, halomethoxymethyl, ethoxymethyl, haloethoxymethyl, propoxymethyl, ethylaminocarbonylmethyl, ethylaminocarbonylethyl, dimethoxyethyl, propynylaminocarbonylmethyl, N-phenyl-N-methyl-amino, haloethylaminocarbonylmethyl, haloethylaminocarbonylethyl, tetrahydrofuryl, methylaminocarbonylmethyl, (N,N-dimethylamino)-carbonylmethyl, propylaminocarbonylmethyl, yclopropylaminocarbonylmethyl, propenylaminocarbonylmethyl, haloethylaminocarbonylcyclopropyl,
• R4=hydrogen, ethyl, methoxymethyl, halomethoxymethyl, ethoxymethyl, haloethoxymethyl, propoxymethyl, methylcarbonyl, ethylcarbonyl, propylcarbonyl, cyclopropylcarbonyl, methoxycarbonyl, methoxymethylcarbonyl, aminocarbonyl, ethylaminocarbonylmethyl, ethylaminocarbonylethyl, dimethoxyethyl, propynylaminocarbonylmethyl, haloethylaminocarbonylmethyl, cyanomethylaminocarbonylmethyl, or haloethylaminocarbonylethyl;
• or
• R3 and R4 together form a substituent selected from the group consisting of:
• wherein ZA=hydrogen, halogen, cyano, halomethyl, or CF3;
• and a veterinary acceptable liquid carrier vehicle wherein the liquid carrier vehicle comprises glycofurol as a solvent.