Compositions and methods comprising celecoxib or related compounds and dextromethorphan
OwnerHerriot Tabuteauinventor
Life of this patent
Estimating the term…
Abstract
Pain and/or neurological disorders may be treated by administering a therapeutically effective amount of dextromethorphan and a therapeutically effective amount of a compound such as celecoxib that inhibits the metabolism of dextromethorphan, to a person in need thereof. The two compounds may be administered separately, or in a single dosage form or composition as described herein.
Claims32
A method of increasing dextromethorphan plasma levels in a human being that is an extensive metabolizer of dextromethorphan, comprising co-administering celecoxib with dextromethorphan to the human being.
A method of inhibiting metabolism of dextromethorphan, comprising administering celecoxib to a human being, wherein the human being is an extensive metabolizer of dextromethorphan, and wherein dextromethorphan is present in the body of the human being at the same time as celecoxib.
A method of correcting extensive metabolism of dextromethorphan, comprising administering celecoxib to a human being in need thereof.
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
An oral dosage form comprising at least 20 mg of dextromethorphan and an effective amount of celecoxib to inhibit the metabolism of dextromethorphan in a human being that is an extensive metabolizer of dextromethorphan.
Dependencies are inferred from the claim text.