US 2013/0274272 A1 · METHYL/DIFLUOROPHENYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS, METHYL-PYRIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS, AND METHYL-PYRIMIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS

Abstract

The present disclosure provides methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory disease, having the structure of Formula (I): wherein R1, R2, R3 and X are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating p38 kinase mediated diseases using the compound.

Claims14

Dependent claims

A compound of Formula (I):

or a pharmaceutically acceptable salt thereof, wherein:
X is CH or N;
R1 is chloro or bromo;
R2 is —H or methyl;
and
R3 is selected from the group consisting of 2,4-difluoro-3-methylphenyl, 2,4-difluoro-5-methylphenyl, 5-methylpyridin-3-yl, and 4-methylpyrimidin-2-yl.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

13/913,350Filed 7 Jun 2013

Priority

6 Dec 2010

Published

17 Oct 2013

Term ends

Not estimatedThe source records don’t support an estimate.

Classification8 codes

C07D 213/69
Oxygen or sulfur atoms: two or more oxygen atoms
A61K 31/4412
Non condensed pyridines; Hydrogenated derivatives thereof: having oxo groups directly attached to the heterocyclic ring
A61K 31/444
Containing further heterocyclic ring systems: containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
A61K 31/506
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim: not condensed and containing further heterocyclic rings

Family

Application61/420,074Us provisional application · filed 6 Dec 2010

Application13/312,924Continuation in part · filed 6 Dec 2011

Application13/913,350Continuation in part

US 2012/0142709 A1Published application

US 9,359,300 B2Related patent

US 2013/0274272 A1This patent

From the US filing history. Foreign family members aren’t listed.

Methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds

Life of this patent

Methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds

Life of this patent

Abstract

Claims14