Pharmaceutical compositions of linezolid
AssigneeHetero Research Foundation
InventorsBandi Parthasaradhi Reddy, Podili Khadgapathi, Goli Kamalakar Reddy, Lekkala Vamshi Krishna
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Abstract
The present invention relates to stable pharmaceutical compositions comprising linezolid crystalline Form III with one or more pharmaceutically acceptable excipients, wherein the composition retains linezolid in its original crystalline form.
Claims13
A stable pharmaceutical composition comprising linezolid Form III and, polacrilin potassium as disintegrant, prepared by a dry granulation process, wherein the composition retains linezolid in its original Form III crystalline form.
The process of claim 8, comprising
- mixing linezolid Form III, hydroxypropylmethyl cellulose as a binder and polacrilin potassium as a disintegrant, and
- directly compressing the mixture into a tablet.
A process for preparing a stable pharmaceutical composition comprising linezolid form III, comprising
- providing a mixture comprising linezolid Form III, polacrilin potassium as a disintegrant, and at least one pharmaceutically acceptable excipient, and
- wet granulating, dry granulating, spray granulating or directly compressing the mixture,
- wherein the stable pharmaceutical composition retains linezolid in Form III.
A process for preparing a stable pharmaceutical composition comprising linezolid Form III and at least one pharmaceutically acceptable excipient, comprising
- wet granulating the linezolid Form III and the pharmaceutically acceptable excipient using 10% w/w of water based on total weight of the core tablet as a granulation solvent, wherein the stable pharmaceutical composition retains more than 80% crystallinity of linezolid form III.
(canceled)
Dependencies are inferred from the claim text.