Substituted 2-[2-(phenyl) ethylamino] alkaneamide derivatives and their use as sodium and/or calcium channel modulators

A method for treating or preventing a cognitive or psychiatric disorder, comprising the step of administering to a patient in need thereof an effective amount of a compound of formula (I):

• wherein:
• X is —O—, —S— or —SO2—;
• Y is hydrogen, —OH or —O(C1-C4)alkyl;
• Z is ═O or ═S;
• R is —(C3-C10)alkyl;
• ω-trifluoro(C3-C10)alkyl;
• R1 and R2 are, independently, hydrogen, hydroxy, (C1-C8)alkoxy, (C1-C8) alkylthio, halo, trifluoromethyl or 2,2,2-trifluoroethyl;
• or one of R1 and R2 is ortho to R—X— and, taken together with the same R—X—, represents a
• group where R0 is —(C2-C9)alkyl;
• R3 and R′3 are, independently, hydrogen or —(C1-C4)alkyl;
• R4 and R5 are, independently, hydrogen, —(C1-C4)alkyl;
• or R4 is hydrogen and R5 is —CH2—OH, —CH2—O—(C1-C6)alkyl, —CH(CH3)—OH, —(CH2)2—S—CH3, benzyl or 4-hydroxybenzyl;
• or
• R4 and R5, taken together with the adjacent carbon atom, form a (C3-C6)cycloalkyl residue;
• R6 and R7 are independently hydrogen or —(C1-C6)alkyl;
• or taken together with the adjacent nitrogen atom form a 5- or 6-membered monocyclic saturated heterocycle, optionally containing —O—, —S— or —NR8—, wherein R8 is hydrogen or —(C1-C6)alkyl;
• with the proviso that when X is —S— or —SO2—, then Y is not —OH or —O(C1-C4)alkyl;
• its pharmaceutically acceptable salts and the isolated optical isomers or mixtures of optical isomers of the compound and their pharmaceutically acceptable salts.