Combination Medicaments for Treating Bacterial Infections
AssigneeBasilea Pharmaceutica AG
InventorsEric Desarbre, Malcolm G.P. Page
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Abstract
Use of a monobactam antibiotic of formula (I) wherein the oxyimino group i.e. >C═N—O— has Z-orientation, or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the treatment of a bacterial infection in combination with a carbapenem antibiotic or a pharmaceutically acceptable salt thereof.
Claims24
A pharmaceutical product comprising a monobactam antibiotic having the oxyimino moiety >C═N—O—, said antibiotic having the formula (I)
- wherein the oxyimino moiety has the Z-orientation,
- or a pharmaceutically acceptable salt thereof and at least one carbapenem antibiotic,
- or a pharmaceutically acceptable salt thereof.
A monobactam antibiotic containing an oxyimino moiety >C═N—O—, wherein said antibiotic is a compound of formula (I)
- wherein the oxyimino moiety has a Z-orientation, or a pharmaceutically acceptable salt thereof, said antibiotic being in substantially crystalline form.
A packaged kit for treating bacterial infection in mammals comprising at least two dosage units of a pharmaceutical antibiotic, each dosage unit being in a separate container, one of said containers containing a monobactam antibiotic having an oxyimino moiety >C═N—O—, said antibiotic having the formula (I)
- wherein the oxyimino moiety has the Z-orientation, or a pharmaceutically acceptable salt thereof and a second container containing carbapenem antibiotic, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.