Anti-ssx-2 t cell receptors and related materials and methods of use
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Serv
InventorsRichard A. Morgan, Nachimuthu Chinnasamy, Steven A. Rosenberg
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Abstract
The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for synovial sarcoma X Breakpoint (SSX)-2. The invention further provides related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells. Further provided by the invention are antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are further provided by the invention.
Claims34
An isolated or purified T cell receptor (TCR) having antigenic specificity for synovial sarcoma X Breakpoint (SSX)-2 (SEQ ID NO:
- 1).
34-37. (canceled)
Dependencies are inferred from the claim text.