Selective anticancer chimeric peptide
AssigneesStella Pharma Corporation, Koji Kawakami
InventorsKoji Kawakami, Masayuki Kohno, Tomohisa Horibe, Oumi Nakajima, Mari Haramoto, Liying Yang
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AssigneesStella Pharma Corporation, Koji Kawakami
InventorsKoji Kawakami, Masayuki Kohno, Tomohisa Horibe, Oumi Nakajima, Mari Haramoto, Liying Yang
Estimating the term…
It is an object of the present invention to provide a substance usable as an anticancer agent or DDS, which has intracellular stability, which is capable of evading side effects from functional disorder with respect to normal cells, or which has instantaneous effect. The inventors developed a novel chimeric peptide targeting cancer cells which overexpress EGFR or the like using a binding peptide such as a peptide sequence binding to EGFR, and a lytic peptide sequence, thereby solving such an object. Particularly, by using a chimeric peptide including an EGF receptor-binding peptide or the like and a cytotoxic peptide, this object was solved.
-56. (canceled)
A chimeric peptide comprising a receptor-binding peptide and a cytotoxic peptide, wherein the receptor-binding peptide is a neuropilin receptor-binding peptide.
Dependencies are inferred from the claim text.