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US 2013/0274197 A1Published application
Benzodiazepinone compounds useful in the treatment of skin conditions
AssigneeThe Regents of the University of Michigan
InventorGary D. Glick
Life of this patent
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Abstract
The present invention provides a family of benzodiazepinone compounds and pharmaceutical compositions thereof. The present invention also provides methods of treating certain skin conditions, e.g., atopic dermatitis, rosacea, or psoriasis, by administering a benzodiazepinone and methods of reducing the proliferation of keratinocyte cells by exposing such cells to a benzodiazepinone.
Claims39
A compound represented by formula I:
- including salts, esters and prodrugs thereof, wherein
- R1 is H or C1-6 alkyl;
- R2 is H or C1-6 alkyl;
- R3 is C1-6 alkyl;
- R4 is hydroxyl or fluoro;
- the stereochemical configuration at a stereocenter in a compound represented by formula I is R, S, or a mixture thereof;
- and
- provided that said compound is not
5 more elements
Dependencies are inferred from the claim text.