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US 2013/0274174 A1Published application
Therapeutic combination of daptomycin and protein synthesis inhibitor antibiotic, and methods of use
AssigneeTrius Therapeutics, Inc.
InventorsKenneth F. Bartizal, Jeffrey B. Locke, Karen Joy Shaw, Philippe G. Prokocimer
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Abstract
A therapeutic combination comprises an antibacterially effective amount of daptomycin, and an amount of protein synthesis inhibitor antibiotic effective to prevent the development of daptomycin non-susceptibility in bacteria. Related combination therapies and methods are also included.
Claims30
A therapeutic combination comprising
- an antibacterially effective amount of daptomycin, and
- an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof, effective to prevent the development of daptomycin non-susceptible bacterial strains
- wherein,
- Het is tetrazolyl or oxadiazolyl;
- ring A is unsubstituted or has at least one fluorine substituent;
- R7 is H, PO(OH)2 or PO(O)2−2(M+)2, wherein M+ is a metal cation;
- R3 is H or unsubstituted C1-4 alkyl group.
4 more elements
Dependencies are inferred from the claim text.