Single domain tdf-related compounds and analogs thereof
OwnerWilliam D. Carlson, Peter C. Keckinventors
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Abstract
The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.
Claims27
A compound comprising an amino acid sequence selected from the group consisting of, SEQ ID NOs:1-208, polynucleotides encoding SEQ ID NOs:1-208, and variants, analogs, homologs, or fragments thereof.
8-12. (canceled)
14-15. (canceled)
25-27. (canceled)
A method of treating a pathological state in a mammal, the method comprising administering to the mammal a compound in an amount that is sufficient to alleviate the pathological state, wherein the compound is a compound having an amino acid sequence at least 90% identical to a compound comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:1-208.
(canceled)
A method of treating a tissue differentiation factor-associated disorder in a mammal, the method comprising administering to the mammal at least one compound which modulates the expression or activity of a compound selected from the group consisting of SEQ ID NOs:1-208, or a fragment, variant, or homolog thereof.
A compound for use in treating a tissue differentiation factor-associated disorder, wherein the compound is selected from the group consisting of SEQ ID NOs:1-208.
The use of a compound for the manufacture of a medicament for treatment of a tissue differentiation factor-associated disorder, wherein the compound is selected from the group consisting of SEQ ID NOs:1-208.
34-40. (canceled)
Dependencies are inferred from the claim text.