Analytical Methods and Arrays for Use in the Same
AssigneeSenzagen AB
InventorsMalin Lindstedt, Carl Arne Krister Borrebaeck, Henrik Johansson, Ann-Sofie Albrekt
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Abstract
The present invention relates to an in vitro method for identifying agents capable of inducing sensitization of human skin and arrays and diagnostic kits for use in such methods. In particular, the methods include measurement of the expression of the biomarkers listed in Table 3A and/or 3B in MUTZ-3 cells exposed to a test agent.
Claims35
An in vitro method for identifying agents capable of inducing sensitization of mammalian skin comprising or consisting of the steps of:
- a) exposing a population of dendritic cells or a population of dendritic-like cells to a test agent;
- and
- b) measuring in the cells the expression of one or more biomarker(s) selected from the group defined in Table 3;
- wherein the expression in the cells of the one or more biomarkers measured in step (b) is indicative of the sensitizing effect of the sample to be tested.
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Use of two or more biomarkers selected from the group defined in Table 3A or Table 3B in combination for identifying hypersensitivity response sensitising agents.
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Dependencies are inferred from the claim text.