Nanoparticles of cerium and amino acids
AssigneeCerion Enterprises, LLC
InventorsWendi Ann Costanzo, Kenneth Joseph Reed, Bradford Michael Stadler
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Abstract
A process for making nanoparticles of biocompatible materials is described, wherein an aqueous reaction mixture comprising cerous ion, an α-amino acid, an oxidant and water is provided along with temperature conditions to effectively form nanoparticles. These biocompatible nanoparticles may be further conjugated to biologically active agents, such as plasmid DNA, siRNA or proteins, such that a cell transfection agent is formed.
Claims20
A process of making nanoparticles, comprising:
- (a) forming a reaction mixture comprising cerous ion, an α-amino acid, an oxidant, and water;
- and
- (b) forming a dispersion of nanoparticles from the reaction mixture.
A nanoparticle comprising an α-amino acid and a metal.
A process of making a conjugate, comprising:
- contacting a nanoparticle comprising an α-amino acid and a metal, with a biologically active agent.
A conjugate, comprising:
- a nanoparticle comprising an α-amino acid and a metal;
- and
- a biologically active agent.
A process of transfecting a cell, comprising:
- contacting a cell with a conjugate comprising 1) a nanoparticle comprising an α-amino acid and a metal, and 2) a biologically active agent.
Dependencies are inferred from the claim text.