Hydrogenase Fusion Protein for Improved Hydrogen Production
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsPhillip Richard Smith, James R. Swartz
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Abstract
Compositions of a fusion protein comprising a spatially tethered ferredoxin-NADP-reductase (FNR) and an active [FeFe] hydrogenase, genetic sequences encoding such fusion proteins, and methods of use thereof are provided. The fusion proteins of the invention link an FNR polypeptide to an active [FeFe] hydrogenase through a polypeptide linker. The fusion protein facilitates improved electron transfer through a ferredoxin, and allows direct electron transfer from NADPH to the hydrogenase.
Claims21
A fusion protein comprising an active FeFe hydrogenase joined through a polypeptide linker to an active ferredoxin-NADP-reductase (FNR).
Dependencies are inferred from the claim text.