PREPARATION OF (3aS,7aR)-HEXAHYDROISOBENZOFURAN-1(3H)-ONE BY CATALYZED BIOLOGICAL RESOLUTION OF DIMETHYL CYCLOHEXANE-1,2-DICARBOXYLATE
AssigneeAbbott Products Operations AG
InventorMichael Charles Lloyd
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Abstract
Processes for the synthesis of (3aS,7aR)-hexahydroisobenzofuran-1-(3H)-one, comprising comprising enzymatic hydrolysis of dimethyl cyclohexane-1,2-dicarboxylate to form (1S,2R)-2-(methoxycarbonyl) cyclohexanecarboxylic acid. The enzyme can be from a non-mammalian source.
Claims18
A process for preparing (3aS,7aR)-hexahydroisobenzofuran-1(3H)- one, comprising hydrolyzing dimethyl cyclohexane-1,2-dicarboxylate in the presence of an enzyme that is not derived from a mammalian source.
A process for preparing (1S,2R)-2-(methoxycarbonyl)cyclohexane-carboxylic acid, comprising hydrolyzing dimethyl cyclohexane-1,2- dicarboxylate in the presence of an enzyme that is not derived from a mammalian source.
Dependencies are inferred from the claim text.