Method of conferring a protective immune response to norovirus
AssigneeTakeda Vaccines, Inc.
InventorsCharles RICHARDSON, Thomas S. VEDVICK, Thomas R. Foubert, Robert F. BARGATZE, William TINO
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Abstract
The present invention relates to vaccine compositions comprising Norovirus antigens and adjuvants, in particular, mixtures of monovalent VLPs and mixtures of multivalent VLPs, and to methods of conferring protective immunity to Norovirus infections in a human subject.
Claims18
A method of eliciting protective immunity against Norovirus in a human comprising administering to the human a vaccine comprising Norovirus virus-like particles (VLPs) and at least one adjuvant, wherein the adjuvant is not a toxin adjuvant, wherein a geometric mean serum titer of Norovirus-specific functional antibodies greater than 40 as measured by a carbohydrate blocking assay is indicative of protective immunity.
Dependencies are inferred from the claim text.