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US 2013/0273104 A1Published application
Adjuvanted Influenza Vaccines for Pediatric Use
AssigneeNovartis AG
InventorsAudino PODDA, Nicola GROTH, Michele Pellegrini
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AssigneeNovartis AG
InventorsAudino PODDA, Nicola GROTH, Michele Pellegrini
Estimating the term…
An influenza vaccine adjuvanted with a sub-micron oil-in-water emulsion elicits significantly higher immune responses in human pediatric populations. Compared to an existing unadjuvanted pediatric influenza vaccine, the adjuvanted vaccines provided herein can induce in children a longer persistence of high serum antibody titers and also longer seroconversion and seroprotection. The improvement in immune responses is seen for both influenza A virus and influenza B virus strains, but it is particularly marked for influenza B virus. Moreover, while the existing vaccine provides poor immunity in children after a single dose, the adjuvanted vaccine provides high seroprotection rates against the influenza A virus H3N2 subtype even after a single dose. Furthermore, the adjuvanted vaccine offers significantly better seroprotection against mismatched strains of influenza A virus.
A composition in unit dosage form, wherein:
A composition in unit dosage form, wherein:
A kit for preparing an immunogenic composition for use in immunizing a child, wherein the kit comprises (i) a first kit component comprising an influenza B virus strain antigen and (ii) a second kit component comprising an adjuvant, wherein the adjuvant comprises an oil-in-water emulsion in which the majority of oil droplets have a diameter of less than 1 μm and the oil droplets comprise squalene;
A kit for preparing an immunogenic composition for use in immunizing a child, wherein the kit comprises a first kit component comprising an influenza B virus strain antigen for mixing with a second component comprising an adjuvant, wherein the adjuvant comprises an oil-in-water emulsion in which the majority of oil droplets have a diameter of less than 1 μm and the oil droplets comprise squalene;
A kit for preparing an immunogenic composition for use in immunizing a child, wherein the kit comprises a first kit component comprising an adjuvant for mixing with a second component comprising an influenza B virus strain antigen, wherein the adjuvant comprises an oil-in-water emulsion in which the majority of oil droplets have a diameter of less than 1 μm and the oil droplets comprise squalene;
Dependencies are inferred from the claim text.