Use of a dna expression construct
AssigneeMologen AG
InventorsWolfgang Walther, Peter M. Schlag, Dennis Kobelt, Manuel Schmidt
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Abstract
The present invention relates to the use of a DNA expression construct comprising a dumbbell-shaped circular strand of deoxyribonucleic acids and provides such a construct with a double-stranded stem and single-stranded loops located at both ends of the stem, wherein the stem comprises complementary deoxyribonucleic acids of the circular strand with a promotor sequence, a coding sequence and a termination signal to be administered by jet injection for the treatment of cancer.
Claims13
A method for the treatment of cancer comprising administering by jet injection a dumbbell-shaped linear, covalently closed DNA expression construct with a double-stranded stem and single-stranded loops located at both ends of the stem, wherein the stem of complementary deoxyribonucleic acids of a circular DNA strand comprises a promotor sequence, a coding sequence and a termination signal.
Dependencies are inferred from the claim text.