Amino acyl trna synthetases for modulating inflammation
AssigneeaTyr Pharma, Inc.
InventorsJeffry Dean Watkins, Alain Philippe Vasserot, Leslie Ann Greene, Ryan Andrew Adams, Kyle P. Chiang, Wei Zhang, Kristi Helen Piehl, Fei Hong, Alina He
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Abstract
Inflammatory and other cellular response-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of inflammation, such as inflammatory diseases or conditions.
Claims24
1-114. (canceled)
A therapeutic composition, comprising a pharmaceutically-acceptable carrier and an isolated histidyl-tRNA synthetase (HRS) polypeptide selected from (a) a polypeptide that comprises SEQ ID NO:28, (b) a fragment of (a) comprising at least 500 contiguous amino acids of SEQ ID NO:28, and (c) a variant of (a) having at least 95% identity to SEQ ID NO:28, where the HRS polypeptide has an anti-inflammatory activity and is at least about 90% pure, and where the composition is sterile and pyrogen-free.
Dependencies are inferred from the claim text.