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US 2013/0261125 A1Published application
Indazole derivatives useful as erk inhibitors
AssigneeMerck Sharp & Dohme Corp.
InventorsGerald W. Shipps, JR., Xiaohua Huang, Yongqi Deng, Liang Zhu, Alan B. Cooper, Binyuan Sun, Abdelghani Achab, Sie-Mun Lo
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Abstract
The present invention provides a compound of the Formula I, or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2, R3, m and are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions that comprise the above compounds, and methods of treating cancer using the same.
Claims20
A compound of Formula I
- or a pharmaceutically acceptable salt or solvate thereof, wherein:
- R is H or alkyl;
- R1 is selected from the group consisting of aryl and heteroaryl, wherein when said aryl or heteroaryl has two substituents on adjacent ring atoms, said substituents together with the ring atoms to which they are attached, optionally form a five- or six-membered heteroaryl or a six-membered aryl;
- R2 is H or alkyl;
- m is 1 ort;
- n is 1 or 2;
- each R3 independently is selected from the group consisting of halo, hydroxyl, alkoxy, alkyl, aryloxy, —NR4R5, —C(═O)NR4R5, —N(R4)—C(═O)—R5;
- —C(═O)-aryl, —C(═O)—O-alkyl, —C(═N—OH)-aryl, and —C(═O)OH;
- and
- R4 and R5 independently are hydrogen or alkyl.
7 more elements
The compound of claim 9, wherein said R1 aryl is selected from the group consisting of:
Dependencies are inferred from the claim text.