Method of improving response to chemotherapy by administering a phospholipid together with chemotherapeutic agents, and formulations therefor

A method for improving efficacy of a chemotherapeutic treatment of a disease or condition, wherein the method comprises:

• (a) administering a therapeutic amount of at least one chemotherapeutic agent to an individual afflicted with a disease or a condition that is treatable by said at least one agent;
• (b) also administering to the individual at least one phospholipid or a material containing at least one said phospholipid, wherein the at least one phospholipid is administered in an amount sufficient to facilitate entry of said at least one chemotherapeutic agent into cells of said individual negatively affected by the disease or condition;
• and
• (c) further administering a sufficient dosage of a blood-thinning agent to the individual to mitigate risk of developing blood clots attributable to administration of the at least one chemotherapeutic agent,
• wherein steps (a), (b) and (c) are performed in any order but in sufficient time proximity such that the effect of the at least one phospholipid in facilitating entry of said at least one chemotherapeutic agent into cells of said afflicted individual at least partially overlaps with the therapeutic effect of said at least one chemotherapeutic agent.

A formulation that improves efficacy of chemotherapeutic treatment of an individual afflicted with a condition or a disease treatable with one or more chemotherapeutic agents, said formulation comprising:

• (a) at least one chemotherapeutic agent capable of treating a disease or condition with which said individual is afflicted;
• and
• (b) at least one phospholipid or a material containing at least one said phospholipid, wherein the at least one phospholipid acts to facilitate entry of the at least one chemotherapeutic agent into cells of said individual,
• wherein the at least one chemotherapeutic agent and the at least one phospholipid or the material containing said at least one phospholipid are administered in any order, but in sufficient time proximity such that the effect of the at least one phospholipid of facilitating entry of said at least one chemotherapeutic agent into cells of said afflicted individual at least partially overlaps with the therapeutic effect of said at least one chemotherapeutic agent.

A formulation that improves efficacy of chemotherapeutic treatment of an individual afflicted with a condition or a disease treatable with one or more chemotherapeutic agents, said formulation comprising:

• (a) at least one chemotherapeutic agent capable of treating a disease or condition with which said individual is afflicted;
• (b) at least one phospholipid or a material containing said at least one phospholipid, wherein the at least one phospholipid acts to facilitate entry of the at least one chemotherapeutic agent into cells of said individual;
• and
• (c) a sufficient dosage of a blood-thinning agent to mitigate risk to the individual of developing blood clots attributable to administration of the at least one chemotherapeutic agent,
• wherein the at least one chemotherapeutic agent and the at least one phospholipid or the material containing said at least one phospholipid are administered in any order, but in sufficient time proximity such that the effect of the at least one phospholipid of facilitating entry of said at least one chemotherapeutic agent into cells of said afflicted individual at least partially overlaps with the therapeutic effect of said at least one chemotherapeutic agent.