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US 2013/0261079 A1Published application
High molecular weight heparosan polymers and methods of production and use thereof
AssigneeThe Board of Regents of the University of Oklahoma
InventorsPaul L. DeAngelis, Phillip Pummill, Regina C. Visser
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Abstract
High molecular weight heparosan polymers are described, as are methods of producing and using the high molecular weight heparosan polymers.
Claims19
A method for recombinantly producing a high molecular weight heparosan polymer, the method comprising the steps of:
- culturing a recombinant host cell containing a nucleotide sequence encoding a Pasteurella heparosan synthase under conditions appropriate for the expression of the heparosan synthase;
- and
- isolating heparosan polymer produced by the heparosan synthase, wherein the isolated heparosan polymer is biocompatible with a mammalian patient and biologically inert within extracellular compartments of a mammalian patient, and wherein the isolated heparosan polymer is represented by the structure (-GlcUA-beta-1,4-GlcNAc-alpha-1,4-)n, wherein n is a positive integer greater than or equal to 2,000.
A method of augmenting tissue in a mammalian patient, comprising the steps of:
- administering an effective amount of a biomaterial composition to a mammalian patient, the biomaterial composition comprising an isolated heparosan polymer that is biocompatible with the mammalian patient and biologically inert in extracellular compartments of the mammalian patient, wherein the isolated heparosan polymer is represented by the structure (-GlcUA-beta-1,4-GlcNAc-alpha-1,4-)n, wherein n is a positive integer greater than or equal to 2,000.
19-28. (canceled)
Dependencies are inferred from the claim text.