Method of Constructing a Data Structure

A method of constructing a data architecture for use in identifying connections between perturbagens and genes associated with skin tone, comprising:

• (a) providing a gene expression profile for a control human cell, wherein the control cell is from a human cell line selected from the group consisting of keratinocyte, fibroblast, melanocyte and melanoma cell lines;
• (b) generating a gene expression profile for a human cell exposed to at least one perturbagen, wherein the cell is selected from the same cell line as the control cell;
• (c) identifying genes differentially expressed in response to the at least one perturbagen by comparing the gene expression profiles of (a) and (b);
• (d) creating an ordered list comprising identifiers representing the differentially expressed genes, wherein the identifiers are ordered according to the differential expression of the genes;
• (e) storing the ordered list as an instance on a computer readable medium, wherein the instance is a keratinocyte, fibroblast, melanocyte or melanoma instance according to the selection in (a);
• and
• (f) constructing a data architecture of stored instances by repeating (a) through (e), wherein the at least one perturbagen of step (b) is different qualitatively or quantitatively for each instance.