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US 2013/0259945 A1Published application
Anti-malaria compositions and methods
AssigneeArtificial Cell Technologies, Inc.
InventorThomas J. Powell
Life of this patent
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Abstract
Multilayer films comprise polypeptide epitopes from Plasmodium falciparum, specifically a circumsporozoite T1, B or T* epitope. The multilayer films are capable of eliciting an immune response in a host upon administration to the host. The multilayer films can include at least one designed peptide that includes one or more polypeptide epitopes from a Plasmodium protozoan.
Claims26
A composition comprising
- a first multilayer film comprising a plurality of oppositely charged polyelectrolyte layers, wherein one of the polyelectrolyte layers in the multilayer film comprises a first antigenic polyelectrolyte,
- wherein the first antigenic polyelectrolyte comprises a Plasmodium falciparum circumsporozoite T1, B or T* epitope covalently linked to a first polyelectrolyte, and
- wherein the polyelectrolytes in the multilayer film comprise a polycationic material or a polyanionic material having a molecular weight of greater than 1,000 and at least 5 charges per molecule.
A composition comprising
- a first multilayer film comprising a plurality of oppositely charged polyelectrolyte layers, wherein one of the polyelectrolyte layers in the multilayer film comprises a first antigenic polypeptide,
- wherein the first antigenic polypeptide comprises a Plasmodium falciparum circumsporozoite T1, B and T* epitopes covalently linked to a first polypeptide, and
- wherein the polyelectrolytes in the multilayer film comprise a polycationic material or a polyanionic material having a molecular weight of greater than 1,000 and at least 5 charges per molecule.
Dependencies are inferred from the claim text.