Biodegradable Drug Delivery Composition
AssigneeDurect Corporation
InventorsWilliam van Osdol, Su Il Yum, Felix Theeuwes, Michael Sekar, John W. Gibson, Keith E. Branham, Huey-Ching Su
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Abstract
The present disclosure provides a biodegradable drug delivery composition including a vehicle and an insoluble component comprising beneficial agent dispersed in the vehicle. Typically, the composition is not an emulsion, but has a low viscosity and further provides for minimized initial burst and sustained release of the beneficial agent over time. Also provided, are kits including the biodegradable drug delivery composition or components thereof, as well as methods of making and using the biodegradable drug delivery composition.
Claims21
-22. (canceled)
A composition comprising:
- a vehicle comprising
- a biodegradable polymer present in an amount of from about 5% to about 40% by weight of the vehicle and
- a hydrophobic solvent present in an amount of from about 95% to about 60% by weight of the vehicle;
- and
- an insoluble component comprising beneficial agent dispersed in the vehicle, the insoluble component having a solubility of less than 1 mg/mL in the vehicle at 25° C.,
- wherein the biodegradable polymer comprises an ionizable end group, and
- wherein the insoluble beneficial agent comprises a protein, peptide, nucleic acid, or small molecule drug.
Dependencies are inferred from the claim text.