Use of listeria vaccine vectors to reverse vaccine unresponsiveness in parasitically infected individuals
AssigneesUniversity of Georgia Research Foundation, Inc., The Trustees of the University of Pennsylvania
InventorsDonald A. Harn, JR., Yvonne Paterson, Lisa Mcewen
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Abstract
This invention relates to methods of using a Listeria vaccine vector to induce a Th1 immune response in subjects having persistent Th2 immune response profiles.
Claims23
-123. (canceled)
A method of inducing a Th1 immune response in a subject having a persistent Th2 phenotypic profile, the method comprising the step of administering to said subject a therapeutically effective dose of a Listeria vaccine vector, wherein the Listeria vaccine vector expresses and secretes an antigen fused to an additional immunogenic polypeptide, thereby inducing a Th1 immune response in said subject.
Dependencies are inferred from the claim text.