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US 2013/0259882 A1Published application
Conjugate of Folate and Antibody Preparation Method and Use Thereof
OwnerYing Liuinventor
Life of this patent
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Abstract
Anti-tumor conjugates, which consists of foliate or analogues thereof, linkers, an antibodies such as immunoglobulin G. The linker comprises glutathione, cysteamine or cysteine residue, and further comprises N-hydroxysuccinimide. The Conjugates target folate-receptor-positive tumor cells. Also provided are preparation methods and anti-tumor and anti-autoimmune disease uses of the conjugates.
Claims21
1-27. (canceled)
A conjugate of Formula (I), (II) or (III),
- wherein:
- FOLATE is folate or a folate analogue that binds to a cell surface folate receptor, GSH is glutathione or a compound comprising both a free sulfhydryl and a free amino group, IgG is immunoglobulin G or a monomer of an IgG heavy chain or a Fc fragment thereof,
A pharmaceutical composition comprising an effective amount of a FOLATE-GSH-IgG conjugate of claim 1, and a pharmaceutically acceptable carrier or excipient.
Dependencies are inferred from the claim text.