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AssigneesDSO National Laboratories, National University of Singapore
InventorsPaul Anthony Macary, Ee Ping Evelyn Teoh, Brendon John Hanson, En Wei Teo, Angeline Pei Chiew Lim, Mah Lee Mary Ng, Shee Mei Lok, Petra Eveliina Kukkaro
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Compositions and methods for the treatment or prevention of Dengue virus infection in a vertebrate subject are provided. In particular, human neutralizing monoclonal antibodies to Dengue virus isolated from EBV immortalized B cells derived from patients who have recovered from Dengue infection are disclosed. Methods are provided for administering such antibodies to a vertebrate subject in an amount effective to reduce, eliminate, or prevent relapse from infection.
An isolated antibody or fragment thereof that binds to a Dengue virus serotype 1 envelope protein or fragment thereof, wherein the antibody is a human antibody with neutralizing activity.
An antibody or fragment thereof that binds to a Dengue virus having the binding specificity of 14c10, clone 8.
A method of generating a neutralizing antibody against a Dengue virus, the method comprising the steps of:
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