Radiofluorinated compounds and their preparation

A method of diagnosis comprising examining a human or animal body with a diagnostic device and compiling data from the examination, wherein the body is preadministrated with a compound of formula (7):

• wherein R1 denotes H or C1-C4 alkyl, Spacer denotes a C1-C4 alkylene group optionally interrupted by an oxygen atom, R2 denotes a bio-molecule residue having at least one free amino function, and X denotes a physiological acceptable anion.

A method of diagnosis comprising administration of a compound of formula (7):

• wherein R1 denotes H or C1-C4 alkyl, Spacer denotes a C1-C4 alkylene group optionally interrupted by an oxygen atom, R2 denotes a bio-molecule residue having at least one free amino function, and X denotes a physiological acceptable anion,
• to a human or animal body, examining the body with a diagnostic device and compiling data from the examination.

Radiopharmaceutical composition comprising a compound of formula (7)

• wherein R1 denotes H or C1-C4 alkyl, Spacer denotes a C1-C4 alkylene group optionally interrupted by an oxygen atom, R2 denotes a bio-molecule residue having at least one free amino function, and X denotes a physiological acceptable anion, optionally together with a solvent or excipient.

Compound of formula (6)

• wherein R1 denotes H or C1-C4 alkyl, Spacer denotes a C1-C4 alkylene group optionally interrupted by an oxygen atom, and X denotes a physiological acceptable anion.

Compound of formula (4)

• wherein R1 denotes H or C1-C4 alkyl and Spacer denotes a C1-C4 alkylene group optionally interrupted by an oxygen atom.

Compound of formula (3):

• wherein R1 denotes H or C1-C4 alkyl and Spacer denotes a C1-C4 alkylene group optionally interrupted by an oxygen atom.

Compound of formula (2):

• wherein R1 denotes H or C1-C4 alkyl, Spacer denotes a C1-C4 alkylene group optionally interrupted by an oxygen atom, and A denotes an amino protection group such as BOC (tert-butyl ester).

Compound of formula (5)

• wherein R1 denotes H or C1-C4 alkyl, Spacer denotes a C1-C4 alkylene group optionally interrupted by an oxygen atom, or R1 and Spacer together with the adjacent nitrogen atom forms a 4-azonia-spiro[3.5]nonyl group, and X denotes a physiological acceptable anion.