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US 2013/0259799 A1Published application
Human gm-csf antigen binding proteins
AssigneeAmgen Inc.
InventorsJacqueline A. Kirchner, Kenneth A. Brasel, Kara Olson, Jose Carlos Escobar, Dauphine Barone
Life of this patent
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Abstract
Antigen binding proteins that bind to human GM-CSF protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of GM-CSF to GM-CSFR, inhibit GM-CSF-induced proliferation and signaling of myeloid lineage cell lines and inhibit GM-CSF-induced activation of human monocytes.
Claims37
An isolated antigen binding protein that binds GM-CSF, comprising:
- A) one or more heavy chain complementary determining regions (CDRHs) selected from the group consisting of:
- (i) a CDRH1 selected from the group consisting of SEQ ID NO:
- 10, 22, 70 94 and 142;
- (ii) a CDRH2 selected from the group consisting of SEQ ID NO:
- 11, 23, 28, 35, 47, 59, 71, 95, 106, 119 and 143;
- (iii) a CDRH3 selected from the group consisting of SEQ ID NO:
- 12, 24, 36, 48, 60, 72, 83, 96, 108, 120, 132, and 144;
- and
- (iv) a CDRH of (i), (ii) and (iii) that contains one or more amino acid substitutions, deletions or insertions of no more than 4 amino acids;
- B) one or more light chain complementary determining regions (CDRLs) selected from the group consisting of:
- (i) a CDRL1 selected from the group consisting of SEQ ID NO:
- 4, 16, 30, 40, 52, 64, 88, 100, 107, 112, 118, 124, 125 and 136;
- (ii) a CDRL2 selected from the group consisting of SEQ ID NO:
- 5, 17, 29, 34, 41, 65, 77, 101, 113, 130, 131 and 137;
- (iii) a CDRL3 selected from the group consisting of SEQ ID NO:
- 6, 18, 42, 46, 66, 78, 84, 89, 90, 102, 114, 126, and 138;
- and
- (iv) a CDRL of (i), (ii) and (iii) that contains one or more amino acid substitutions, deletions or insertions of no more than 4 amino acids;
- or
- C) one or more heavy chain CDRHs of A) and one or more light chain CDRLs of B).
17 more elements
An isolated antigen binding protein that binds GM-CSF, wherein said antigen binding protein comprises:
- A) one or more heavy chain CDRs (CDRHs) selected from the group consisting of:
- (i) a CDRH1 selected from the group consisting of SEQ ID NO:
- 10, 22, 70 94 and 142;
- (ii) a CDRH2 selected from the group consisting of SEQ ID NO:
- 11, 23, 28, 35, 47, 59, 71, 95, 106, 119 and 143;
- (iii) a CDRH3 selected from the group consisting of SEQ ID NO:
- 12, 24, 36, 48, 60, 72, 83, 96, 108, 120, 132, and 144;
- B) one or more light chain CDRs (CDRLs) selected from the group consisting of:
- (i) a CDRL1 selected from the group consisting of SEQ ID NO:
- 4, 16, 30, 40, 52, 64, 88, 100, 107, 112, 118, 124, 125 and 136;
- (ii) a CDRL2 selected from the group consisting of SEQ ID NO:
- 5, 17, 29, 34, 41, 65, 77, 101, 113, 130, 131 and 137;
- (iii) a CDRL3 selected from the group consisting of SEQ ID NO:
- 6, 18, 42, 46, 66, 78, 84, 89, 90, 102, 114, 126, and 138;
- or
- C) one or more heavy chain CDRHs of A) and one or more light chain CDRLs of B).
13 more elements
Dependencies are inferred from the claim text.