Computer aided diagnostic system incorporating 3d shape analysis of the brain for identifying developmental brain disorders
AssigneeUniversity of Louisville Research Foundation, Inc.
InventorsAyman S. El-Baz, Matthew Nitzken, Manuel F. Casanova
Life of this patent
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Abstract
A computer aided diagnostic system and automated method classify a brain through modeling and analyzing the shape of a brain cortex, e.g., to detect a brain cortex that is indicative of a developmental disorder such as ADHD, autism or dyslexia. A model used in such analysis describes the shape of brain cortices in terms of spherical harmonics required to delineate a unit sphere corresponding to the brain cortex to a model of the brain cortex.
Claims24
A method of classifying a brain, the method comprising:
- receiving image data associated with a head scan including image data of a brain and a brain cortex;
- segmenting image data associated with a brain cortex from the image data associated with the head scan;
- generating a three dimensional (3D) mesh model of the segmented brain cortex;
- mapping the 3D mesh model to a corresponding unit sphere;
- computing a number of spherical harmonics required to delineate the unit sphere to the 3D mesh model;
- and
- classifying the brain using a learned shape model based at least in part on the computed number of spherical harmonics required to delineate the unit sphere to the 3D mesh model.
A method for classifying a brain, the method comprising:
- processing image data including a brain cortex to generate segmented image data for the brain cortex;
- generating a three dimensional (3D) model of the brain cortex based on the segmented image data;
- using at least one processor, performing shape analysis of the 3D model;
- and
- classifying the brain cortex based on the shape analysis of the 3D model.
An apparatus, comprising:
- at least one processor;
- and
- program code configured upon execution by the at least one processor to classify a brain by:
- processing image data including a brain cortex to generate segmented image data for the brain cortex;
- generating a three dimensional (3D) model of the brain cortex based on the segmented image data;
- performing shape analysis of the 3D model;
- and
- classifying the brain cortex based on the shape analysis of the 3D model.
A program product, comprising:
- a computer readable medium;
- and
- program code stored on the computer readable medium and configured upon execution by at least one processor to classify a brain by:
- processing image data including a brain cortex to generate segmented image data for the brain cortex;
- generating a three dimensional (3D) model of the brain cortex based on the segmented image data;
- performing shape analysis of the 3D model;
- and
- classifying the brain cortex based on the shape analysis of the 3D model.
Dependencies are inferred from the claim text.