Methods Of Treating Obesity By Inhibiting Nicotinamide N-Methyl Transferase (NNMT)
AssigneeBeth Israel Deaconess Medical Center, Inc.
InventorsBarbara B. Kahn, Qin Yang, Daniel Kraus
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Abstract
The present invention, in various embodiments, relates to methods of inhibiting NNMT production or activity in a cell, and methods of treating or preventing obesity or a related metabolic condition in a subject in need thereof, comprising administering a nicotinamide N-methyltransferase (NNMT) antagonist. The invention further provides methods of identifying NNMT antagonists useful for treating obesity and related metabolic disorders.
Claims62
A method of inhibiting the expression or activity of a nicotinamide N-methyltransferase (NNMT) protein in a cell, comprising providing the cell with an effective amount of at least one NNMT antagonist, wherein the NNMT antagonist inhibits production of NNMT protein, one or more activities of an NNMT protein, or a combination thereof.
A method of treating or preventing obesity in a subject in need thereof, comprising administering to the subject an effective amount of a nicotinamide N-methyltransferase (NNMT) antagonist, wherein the NNMT antagonist inhibits production of NNMT protein, one or more activities of an NNMT protein, or a combination thereof.
A method of treating or preventing a metabolic disorder in a subject in need thereof, comprising administering to the subject an effective amount of a nicotinamide N-methyltransferase (NNMT) antagonist, wherein the NNMT antagonist inhibits production of NNMT protein, one or more activities of an NNMT protein, or a combination thereof.
A method of identifying a compound useful for treating obesity, comprising:
- (a) administering a test compound to a non-human animal;
- (b) determining the expression or activity of N-methyltransferase (NNMT) in the animal following administration of the compound;
- and
- (c) selecting a compound that inhibits the expression or activity of NNMT in the animal that has been administered the test compound relative to a control non-human animal that was not administered the test compound,
- wherein a decrease in the expression or activity of NNMT in the animal that has been administered the test compound relative to a control non-human animal that was not administered the test compound indicates the test compound is useful for treating obesity.
A method of identifying a compound useful for treating obesity, comprising:
- (a) providing a sample of cells with a test compound;
- (b) determining the expression or activity of N-methyltransferase (NNMT) in the sample in response to the test compound;
- and
- (c) selecting a test compound that inhibits the expression or activity of NNMT in the sample relative to a control sample of cells, wherein the control sample was not provided with the test compound,
- wherein a decrease in the expression or activity of NNMT in the sample that has been provided with the test compound relative to the control sample indicates the test compound is useful for treating obesity.
Dependencies are inferred from the claim text.