# US 2013/0239339 A1 · Composition and method

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- Number: US 2013/0239339 A1
- Document ID: US20130239339A1
- Status: Published application
- Kind: A1
- Application number: 13/698,945
- Filed: 2011-05-12
- Published: 2013-09-19
- Earliest claimed: 2010-05-20
- Assignees: Reckitt & Colman (Overseas) Limited
- Inventors: Gavin Bown; Carl Clayton; Malcolm McKechnie; James Young
- Web page: https://patentgrep.com/patent/US20130239339A1

## CPC

- A61K 8/14: Liposomes; Vesicles
- A61K 8/90: Block copolymers (A61K8/89 takes precedence)
- A61Q 9/04: Depilatories
- A61Q 19/02: for chemically bleaching or whitening the skin
- C11D 17/0039: {Coated compositions or coated components in the compositions, (micro)capsules}
- A61K 2800/244: Endothermic; Cooling; Cooling sensation
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- C11D: DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL

## Abstract

A method of delivering a primary active agent and a secondary active agent to a locus. The method uses a polymersome containing composition. The composition comprises a plurality of polymersome vesicles containing the secondary active agent and a liquid matrix comprising the primary active agent. The polymersome vesicles are capable of being disrupted by the application of mechanical shear.

## Claims

### Claim 1

A method of delivering active agents to a locus comprising:
delivering a primary active agent and a secondary active agent to a locus using a polymersome containing composition;
wherein the composition comprises a plurality of polymersome vesicles containing the secondary active agent and a liquid matrix comprising the primary active agent; and
wherein the polymersome vesicles are capable of being disrupted by a disruption mechanism.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the disruption mechanism comprises one or more of a chemical and mechanical disruption.

### Claim 3 (depends on 2)

The method according to claim 2, wherein the disruption mechanism comprises the application one or more of mechanical shear and change in osmotic potential.

### Claim 4

(canceled)

### Claim 5 (depends on 1)

A method of treating a substrate/surface comprising the method of claim 1.

### Claim 6 (depends on 5)

The method according to claim 5, further comprising quenching the primary active agent after a certain time period.

### Claim 7 (depends on 6)

The method according to claim 6, wherein the second active comprises a quenching agent.

### Claim 8 (depends on 7)

The method according to claim 7, wherein the primary active agent has a high pH.

### Claim 9 (depends on 7)

The method according to claim 7, wherein the quenching agent has a low pH.

### Claim 10 (depends on 9)

The method according to claim 9, wherein the quenching agent comprises an acid.

### Claim 11 (depends on 5)

The method according to claim 5, wherein the substrate/surface is a skin surface.

### Claim 12 (depends on 11)

The method according to claim 11, wherein the primary active agent comprises a depilatory agent.

### Claim 13 (depends on 12)

The method according to claim 12, wherein the depilatory agent comprises alkaline potassium thioglycolate.

### Claim 14 (depends on 1)

The method according to claim 1, wherein the polymersome comprises a vesicle formed from an amphilic di-block copolymer.

### Claim 15 (depends on 1)

The method according to claim 1, wherein the concentration of polymersome is 0.5-1% by weight.

### Claim 16 (depends on 1)

The method according to claim 1, wherein the polymersome is prepared by one or more of extrusion and sonification.

### Claim 17 (depends on 1)

The method according to claim 1, wherein the disruption mechanism comprises the application of mechanical shear; and
wherein the amount of shear is from 0.5-50 Pa.

### Claim 18 (depends on 1)

The method according to claim 1, wherein the disruption mechanism comprises the application of mechanical shear; and
wherein the time needed for shear is less than 10 minutes.

### Claim 19 (depends on 1)

The method according to claim 1, wherein the polymersome comprises a vesicle formed from an admixture of polybutadiene (PBd) and polyethylene oxide (PEO) copolymers;
wherein the concentration of polymersome is 0.5-1% by weight;
wherein the disruption mechanism comprises the application of mechanical shear;
wherein the amount of shear is from 0.5-10 Pa; and
wherein the time needed for shear is less than 3 minutes.

### Claim 20

A composition comprising:
an active agent; and
a quenching agent;
wherein a plurality of polymersome vesicles contains the quenching agent and a liquid matrix comprising the active agent; and
wherein the polymersome vesicles are capable of being disrupted by the application of mechanical shear.