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US 2013/0231318 A1Published application
Ocular implant made by a double extrusion process
AssigneeAllergan, Inc.
InventorsJane-Guo Shiah, Rahul Bhagat, Wendy M. Blanda, Thierry Nivaggioli, Lin Peng, David Chou, David A. Weber
Life of this patent
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Abstract
The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release.
Claims9
-8. (canceled)
A method for making a bioerodible implant for treating a medical condition of the eye, the method comprising:
- a) milling a hydrophilic ended poly(D,L-lactide-co-glycolide) (PLGA) copolymer;
- b) milling a hydrophobic ended poly(D,L-lactide-co-glycolide) (PLGA) copolymer:
- c) blending the milled polymers together with particles of a steroidal anti-inflammatory agent to form a blended mixture comprising hydrophilic ended PLGA, hydrophobic ended PLGA, and a steroidal anti-inflammatory agent, wherein at least about 75% of the particles of the steroidal anti-inflammatory agent have a diameter of less than about 20 μm;
- d) carrying out a first extrusion of the blended mixture to thereby obtain a first extrusion product;
- e) pelletizing the first extrusion product;
- and
- f) carrying out a second extrusion of the pelletized first extrusion product, thereby obtaining a bioerodible implant for treating a medical condition of the eye;
- wherein the implant has a total weight ranging from about 100-5000 μg.
5 more elements
Dependencies are inferred from the claim text.