Methods and systems for providing red blood cell products with reduced plasma
AssigneeFenwal, Inc.
InventorsKyungyoon Min, Katherine Radwanski
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Abstract
Methods and systems for processing and conditioning red blood cells are disclosed. The methods and systems may be used to make a readily transfusible red blood cell product with reduced plasma. In general, the plasma content of the supernatant of the red blood cell product is no greater than about 15%. The red blood cell products are prepared using the disclosed methods and systems remain transfusible for up to 42 days.
Claims21
A container system for the processing of a biological fluid comprising:
- a) an outer container comprising a pair of sealed walls defining an interior chamber;
- b) an inner container contained within said interior chamber, said inner container comprising at least one wall defining an interior chamber of said inner container, wherein said wall is made of a porous material selected to allow passage of only certain components of said biological fluid across said wall;
- c) a port communicating with said interior chamber of said outer container;
- and
- d) at least one port communicating with said inner container.
A method for processing a biological fluid in a container system including an outer container comprising a pair of sealed walls defining an interior chamber, an inner container contained within said interior chamber said inner container comprising at least one wall of a porous material defining an interior chamber of said inner container, said porous material selected to allow passage of only certain components or compounds across said wall, a port communicating with said interior chamber of said outer container and at least one port communicating with said interior chamber of said inner container, the method comprising;
- a) introducing a biological fluid into the interior chamber of one of said inner and outer containers;
- b) introducing an additive solution into the interior chamber of said other of said inner and outer containers;
- and
- c) holding said biological fluid and said additive solution within said container system for a selected period of time.
The method of 11 wherein said plasma comprises no more than approximately 15% of said additive solution, anticoagulant and plasma.
Dependencies are inferred from the claim text.