Two-component tissue adhesive and method for producing same
AssigneeNational Institute for Materials Science
InventorsTetsushi Taguchi, Miyuki Matsuda
Life of this patent
Estimating the term…
Abstract
The present invention addresses the problem of providing: a two-component tissue adhesive having high adhesive strength and high biocompatibility; and a method for producing the two-component tissue adhesive. The present invention involves a two-component tissue adhesive comprising hydrophobically-modified gelatin as a first agent and a cross-linking reagent as a second agent. The hydrophobically-modified gelatin is provided with an amino group and a hydrophobic group on the side chain thereof, and the cross-linking reagent has two or more active ester groups or anhydrides within a single molecule.
Claims7
A two-component tissue adhesive comprising:
- a first agent which contains hydrophobically-modified gelatin that is provided with an amino group and a hydrophobic group on the side chain;
- and
- a second agent which contains a cross-linking reagent that has two or more active ester groups or anhydrides within a single molecule.
A method for producing a two-component tissue adhesive comprising:
- adding an organic molecule that has a hydrophobic group, to a solution in which gelatin has been dissolved, in the presence of an amine, so as to synthesize hydrophobically-modified gelatin by partially substituting amino groups on the side chain of said gelatin with said hydrophobic group, and filling the same in a first container;
- and
- filling a cross-linking reagent that has two or more active ester groups or anhydrides within a single molecule, in a second container.
Dependencies are inferred from the claim text.