Factor involved in latent infection with herpesvirus, and use thereof

A protein being:

• (a) a protein having the amino acid sequence shown in SEQ ID NO:
• 1;
• (b) a protein having an amino acid sequence with a substitution, deletion insertion, and/or addition of five or less amino acids in the amino acid sequence shown in SEQ ID NO:
• 1, the protein having activity of increasing an intracellular calcium concentration or activity of binding to calcium-modulating cyclophilin ligand;
• (c) a protein having, an amino acid sequence having at least 97% identity with the amino acid sequence shown in SEQ ID NO:
• 1, the protein having activity of increasing an intracellular calcium concentration or activity of binding to calcium-modulating cyclophilin ligand;
• (d) a partial fragment of SEQ ID NO:
• 1 having activity of increasing an intracellular calcium concentration or activity of binding to calcium-modulating cyclophilin ligand;
• (e) a protein encoded by a gene comprising an open reading frame region having the nucleotide sequence shown in SEQ ID NO:
• 2;
• or
• (f) a protein encoded by a gene having a nucleotide sequence which is at least 97% identical to the nucleotide sequence shown in SEQ ID NO:
• 2, the protein having activity of increasing an intracellular calcium concentration or activity of binding to calcium-modulating cyclophilin ligand.

A diagnosis kit suitable for performing a diagnosis method for diagnosing whether or not a human subject has a mood disorder, comprising:

• (i) a protein being:
• (a) a protein having the amino acid sequence shown in SEQ ID NO:
• 1;
• (b) a protein having an amino acid sequence with a substitution, deletion, insertion, and/or addition of ten or less amino acids in the amino acid sequence shown in SEQ ID NO:
• 1, the protein having activity of increasing an intracellular calcium concentration or activity of binding to calcium-modulating cyclophilin ligand;
• (c) a protein encoded by a gene comprising an open reading frame region having the nucleotide sequence shown in SEQ ID NO:
• 2;
• or
• (d) a protein encoded by a gene having a nucleotide sequence which is at least 90% identical to the nucleotide sequence shown in SEQ ID NO:
• 2, the protein having activity of increasing an intracellular calcium concentration or activity of binding to calcium-modulating cyclophilin ligand;
• (ii) a partial fragment of the protein (i) having activity of increasing an intracellular calcium concentration or activity of binding to calcium-modulating cyclophilin ligand;
• and
• (iii) an instrument to which the protein (i) or the partial fragment (ii) is immobilized.

A diagnosis kit suitable for performing a diagnosis method for diagnosing whether or not a human subject has a mood disorder, said method comprising the steps of:

• (i) determining, in the human subject, a level of an antibody that recognizes a protein being:
• (a) a protein having the amino acid sequence shown in SEQ ID NO:
• 1;
• (b) a protein having an amino acid sequence with a substitution, deletion, insertion, and/or addition of ten or less amino acids in the amino acid sequence shown in SEQ ID NO:
• 1, the protein having activity of increasing an intracellular calcium concentration or activity of binding to calcium-modulating cyclophilin ligand;
• (c) a protein encoded by a gene comprising an open reading frame region having the nucleotide sequence shown in SEQ ID NO:
• 2;
• or
• (d) a protein encoded by a gene having a nucleotide sequence which is at least 90% identical to the nucleotide sequence shown in SEQ ID NO:
• 2, the protein having activity of increasing an intracellular calcium concentration or activity of binding to calcium-modulating cyclophilin ligand;
• and
• (ii) determining whether or not the human subject has a mood disorder by using, as an indication, the level of the antibody that recognizes said protein in the human subject, and
• wherein the mood disorder is selected from the group consisting of depression and manic-depressive illness.