Multilayer surgicl membrane
AssigneeCase Western Reserve University
InventorsMelissa Knothe Tate, Ulf Knothe
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Abstract
One aspect of the present invention relates to a multilayer surgical membrane. The surgical membrane can include a substantially fluid impermeable outer layer, an inner layer that includes a plurality of fenestrae, and a middle region disposed between the inner and outer layers. The middle region can include at least one channel that extends through the middle region. The middle region can have a first surface in contact with the inner layer. The at least one channel can imbibe fluid under a compressive or tensile load and the fenestrae can deform to exude fluid under the load.
Claims21
A multilayer surgical membrane comprising:
- a substantially fluid impermeable outer layer;
- an inner layer including a plurality of fenestrae;
- and
- a middle region disposed between the inner and outer layers, the middle region including at least one channel that extends through and/or is defined by the middle region;
- wherein the at least one channel imbibes fluid under a compressive or tensile load and the fenestrae deform to exude fluid under the load.
A multilayer surgical membrane for vectorial delivery of periosteal factors from endogenous periosteum to a bone defect comprising:
- a substantially fluid impermeable outer layer;
- an inner layer including a plurality of fenestrae;
- and
- a middle region disposed between the inner and outer layers, the middle region comprising at least one channel that extends through the middle region, the membrane when applied to a bone defect delivering under a compressive or tensile load to the membrane endogenous periosteal factors from endogenous periosteum to the bone defect to facilitate building of tissue at the bone defect.
A surgical sleeve for repairing a bone defect in a subject, comprising:
- a multilayer membrane that extends between a first end and a second end, the multilayer membrane including a substantially fluid impermeable outer layer, an inner layer including a plurality of fenestrae, and a middle region disposed between the inner and outer layers that includes or defines at least one channel, the sleeve delivering endogenous periosteal factor from endogenous periosteum under a compressive or tensile load to the bone defect to facilitate building of tissue at the bone defect.
21-24. (canceled)
Dependencies are inferred from the claim text.