Methods, Systems and Devices for Treatment of Cerebrospinal Venous Insufficiency and Multiple Sclerosis

A method for improving fluid flow through a stenotic body lumen of a human or mammalian subject, said method comprising the step of placing an endovascular or exovascular device in or near the stenotic body lumen, wherein the method further includes at least one additional step selected from the group consisting of:

• a) imaging or measuring the stenotic body lumen and, prior to placing the device, customizing at least part of the device to correspond to the image or measurements of the body lumen;
• b) initially self-expanding the device to a first expanded configuration and, thereafter, further expanding all or part(s) of the device to conform to the anatomy of the stenotic body lumen;
• c) causing the device to communicate with one or more sensors such that the device will exert varying force of the stenotic body lumen in response to information received from the one or more sensors;
• d) placing a plurality of said devices at separate locations corresponding to the anatomy and/or locations of stenotic regions of the body lumen to treat CCVI;
• e) causing the device to pump body fluid through the body lumen to treat CCVI;
• f) forming a full-thickness or partial-thickness cut in or through a wall of the body lumen to relieve constraint or stricture or to otherwise widen the body lumen to treat CCVI;
• g) tuning (e.g., modifying, adjusting shape, adjusting size, etc.) the device after it has been placed in or near the body lumen to treat CCVI;
• h) delivering from the device or by other means an active substance for providing some desired therapeutic effect to treat CCVI;
• or
• i) causing the device or some other means to cause muscle to relax or expand thereby decreasing muscle compression of the stenotic body lumen to treat CCVI.