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AssigneeKorea Ocean Research and Development Institute
InventorsJoung Han Yim, Il Chan Kim, Sung Gu Lee, Dockyu Kim, Se Jong Han, Hyoung Seok Lee, Seung Jin Kim, Tai Kyoung Kim, Pil-Sung Kang, Heeyong Park, Ha Ju Park, Hye Yeon Koh, Mi Ra Park, Yu-Kyeong Park
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The present invention relates to a method for synthesizing ramalin, and more particularly to a method for synthesizing ramalin, which comprises allowing 2-hydrazinylphenol to react with L-glutamic acid having a protected carboxyl group at C-1 and a protected amino group at C-2, and a method for preventing decomposition of the ramalin. According to the present invention, ramalin having excellent antioxidant and anti-inflammatory activities can be synthesized in high yield, and thus can be produced in large amounts. In addition, ramalin can be stably maintained for a long period of time, and thus can be easily used for industrial purposes.
A method for synthesizing ramalin represented by the following formula 1, a salt thereof, a solvate thereof, or a solvate of a salt thereof, the method comprising:
A method for preventing decomposition of ramalin, the method comprising maintaining ramalin in a state of being dissolved in a solvent containing vitamin C (L-ascorbic acid).
Dependencies are inferred from the claim text.