Novel crystalline forms of (1s,2r)-2-(amino methyl)-n,n-diethyl-1-phenyl cyclopropane carboxamide
OwnerRahul Surana, Mahendra G. Dedhiyainventors
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Abstract
The present invention relates to novel crystalline forms of (1S,2R)-2-(amino methyl)-N,N-diethyl-1-phenyl cyclopropane carboxamide. Processes for the preparation of this form, compositions containing the form, and methods of use thereof are also described.
Claims24
A crystalline form of (1S,2R)-2-(amino methyl)-N,N-diethyl-1-phenyl cyclopropane carboxamide having an X-ray powder diffraction pattern comprising characteristic peaks at 12.0, 20.1 and 22.5±0.2 degrees 2θ.
A crystalline form of (1S,2R)-2-(amino methyl)-N,N-diethyl-1-phenyl cyclopropane carboxamide having an X-ray powder diffraction pattern comprising characteristic peaks at 6.0, 12.0 and 20.1±0.2 degrees 2θ.
A crystalline form of (1S,2R)-2-(amino methyl)-N,N-diethyl-1-phenyl cyclopropane carboxamide having an X-ray powder diffraction pattern substantially as shown in FIG. 5.
The crystalline form of claim 14, wherein the X-ray powder diffraction pattern further comprises a characteristic peak at 12.0±0.2 degrees 2θ.
A crystalline form of (1S,2R)-2-(amino methyl)-N,N-diethyl-1-phenyl cyclopropane carboxamide having an X-ray powder diffraction pattern comprising characteristic peaks at 6.0, 13.3 and 23.6±0.2 degrees 2θ.
A pharmaceutical composition comprising the crystalline form of claim 14 and a pharmaceutically acceptable carrier.
A crystalline form of (1S,2R)-2-(amino methyl)-N,N-diethyl-1-phenyl cyclopropane carboxamide having an X-ray powder diffraction pattern comprising characteristic peaks at 14.2, 21.6 and 24.6±0.2 degrees 2θ.
A crystalline form of (1S,2R)-2-(amino methyl)-N,N-diethyl-1-phenyl cyclopropane carboxamide having an X-ray powder diffraction pattern comprising characteristic peaks at 5.9, 18.3 and 36.4±0.2 degrees 2θ.
Dependencies are inferred from the claim text.