Antiviral compounds
AssigneeEirium AB
InventorsGöran Wadell, Karin Edlund, Marten Strand, Emma Andersson, Christopher Öberg, Mikael Elofsson, Ya-Fang Mei
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Abstract
The present invention provides new antiviral compounds and pharmacological compositions comprising these new compounds and their use in the prophylaxis, prevention and treatment of viral infections, particularly adenovirus and herpes virus infections.
Claims11
1-8. (canceled)
A compound selected from:
- Ethyl 2-[3-(benzoylamino)benzoylamino]benzoate
- 2-[[3-(Benzoylamino)benzoyl]amino]benzoic acid
- Ethyl 2-[4-(benzoylamino)benzoylamino]benzoate
- 2-[2-(Acetylamino)benzoylamino]benzoic acid
- 2-[2-(Trimethylacetylamino)benzoylamino]benzoic acid
- 2-[[2-(Cyclohexanecarboxylamino)benzoyl]amino]benzoic acid
- 2-[2-(4-Carboxybutanoylamido)benzoyl]aminobenzoic acid
- 2-[2-(Benzylamino)benzoylamino]benzoic acid
- 2-[2-(2-Fluorobenzoylamino)-benzoylamino]benzoic acid
- 2-[2-(3-Fluorobenzoylamino)-benzoylamino]benzoic acid
- 2-[2-(4-Fluorobenzoylamino)-benzoylamino]benzoic acid
- Ethyl 2-[2-(benzoylamino)benzoylamino]benzoate
- Ethyl 2-[2-(acetylamino)benzoylamino]benzoate
- Ethyl 2-[2-(trimethylacetylamino)benzoylamino]benzoate
- Ethyl 2-[[2-(cyclohexanecarboxylamino)benzoyl]amino]benzoate
- Ethyl 2-[2-(phenylacetylamino)benzoylamino]benzoate
- Ethyl 2-[2-(4-carboxybutanoylamido)benzoyl]aminobenzoate
- Ethyl 2-[[2-(benzylamino)benzoyl]amino]benzoate
- 2-[[2-(Benzoylamino)benzoyl]amino]benzoic acid
- 2-[2-(Acetylamino)benzoylamino]benzoic acid
- 2-[2-(Trimethylacetylamino)benzoylamino]benzoic acid
- 2-[[2-(Cyclohexanecarboxylamino)benzoyl]amino]benzoic acid
- 2-[2-(Phenylacetylamino)benzoylamino]benzoic acid
- 2-[2-(4-Carboxybutanoylamido)benzoyl]aminobenzoic acid
- 2-[2-(Benzylamino)benzoylamino]benzoic acid
- 2-[2-(benzoylamino)benzoylamino]phenylacetic acid
- 2-[2-(benzoylamino)phenylacetylamino]benzoic acid
- 2-[2-(2-fluorobenzoylamino)-benzoylamino]-4-chlorobenzoic acid
- 2-[2-(2-fluorobenzoylamino)benzoylamino]-5-chlorobenzoic acid
- 2-[2-(2-fluorobenzoylamino)-benzoylamino]-4-methoxybenzoic acid
- 2-[2-(2-fluorobenzoylamino)-benzoylamino]-5-methoxybenzoic acid
- 2-[2-(2-fluorobenzoylamino)-benzoylamino]-4,5-difluorobenzoic acid
- 2-[4-chloro-2-(2-fluorobenzoylamino)-benzoylamino]benzoic acid
- 2-[5-chloro-2-(2-fluorobenzoylamino)-benzoylamino]benzoic acid
- 2-[4-methoxy-2-(2-fluorobenzoylamino)-benzoylamino]benzoic acid
- 2-[5-methoxy-2-(2-fluorobenzoylamino)-benzoylamino]benzoic acid, and
- 2-[4,5-difluoro-2-(2-fluorobenzoylamino)-benzoylamino]benzoic acid
- or a pharmaceutically acceptable salt thereof.
A method for the prophylaxis or treatment of a viral disease, the method comprising administering a therapeutically effective amount of a compound of the general formula (I), (II) or (III) or a pharmaceutical acceptable salt thereof to a subject in need of such treatment:
- wherein X1 is selected from —CO—NH—, —NH—,
- X2 is CO—NH—,
- A is selected from the group consisting of, hydrogen, —C1-8alkyl, —C2-8alkenyl, —C2-8alkynyl, —(CH2)nC3-7cycloalkyl, —(CH2)nC2-9heterocycloalkyl, —(CH2)nphenyl, —(CH2)n naphthyl, —(CH2)naryl, —(CH2)nheteroaryl, —(CH2)nNR6R6, —(CH2)nN(R6)CO2C1-8alkyl, —(CH2)nCO2H, —(CH2)nCO2C1-8alkyl,
- wherein alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, phenyl, naphthyl, heteroaryl, and (CH2) are unsubstituted or substituted with one to three substituents independently selected from halogen, oxo, nitro, hydroxy, —NR6R6, —CN, —CF3, —OCF3,
- —C1-6alkyl, —C2-6 alkenyl, —C2-6 alkynyl, —C1-6 alkyloxy;
- R1 is selected from hydrogen, halogen, nitro, hydroxy, —CO2H, —CO2C1-4alkyl, —C1-6alkyl, —C2-6 alkenyl, —C2-6 alkynyl, —C1-6 alkyloxy, —CN, —CF3, —OCF3, tetrazol-5-yl, —CONR6R6;
- R2, R3, R4 and R5 are each independently selected from hydrogen, halogen, oxo, nitro, hydroxy, —NR6R6, —CN, —CF3, —OCF3, —C1-6 alkyl, —C2-6 alkenyl, —C2-6 alkynyl,
- —C1-6 alkyloxy;
- each R6 is independently selected from the group consisting of hydrogen, —C1-8alkyl, —C2-8alkenyl, —C2-8alkynyl, —(CH2)nCO2H;
- and
- n is 0, 1, 2, 3, 4, or 5.
Dependencies are inferred from the claim text.