Coumarin-chalcones as anticancer agents
AssigneeCouncil of Scientific and Industrial Research
InventorsKoneni Venkata Sashidhara, Abdhesh Kumar, Manoj Kumar, Jayanta Sarkar, Sudhir Kumar Sinha
Life of this patent
Estimating the term…
Abstract
The present invention relates to certain coumarin/chalcone compounds or a pharmaceutically acceptable salt thereof. The present invention particularly relates to the coumarin/chalcone compounds as anticancer agents useful for the treatment of cancer. The present invention also relates to the process of preparation of the said compounds.
Claims15
A compound of general formula (VI) or a pharmaceutically acceptable salt thereof,
- wherein:
- R is selected from a group consisting of:
- H, CHO, COCH3, NHCOCH3, F, Cl, Br, NO2, CF3, OCF3, CH3, C2H5, C3H7, straight or branched alkyl chain up to six carbons, straight or branched alkoxy/sulphoxy chain up to six carbons, phenyl or substituted phenyl ring, wherein the substituents in phenyl ring are selected from a group consisting of F, Cl, Br, NO2, CF3, CH3, C2H5, C3H7, straight or branched alkyl chain up to six carbons,
- X is selected from a group consisting of:
- O, S, CH2, NR3, wherein R3=H, CH3, C2H5, C3H7,
- R1 is selected from a group consisting of:
- H, CH3, C2H5, C3H7, straight and branched alkyl chain up to eight carbons, cyclopentyl, cyclohexyl, piperidinyl, unsubstituted or substituted phenyl ring, wherein the substituents in phenyl ring are selected from the group consisting of F, Cl, Br, NO2, CF3, CH3, C2H5, OCH3, OC2H5, and OCF3,
- R2 is selected from a group consisting of:
- CHO, —CH═CHCOR4
- wherein R4 is selected from a group consisting of:
- CH3, C2H5, C3H7, straight and branched alkyl chain up to eight carbons, cyclopentyl, cyclohexyl, heteroaryl, piperidinyl, thienyl, furyl, pyridyl, indolyl and phenyl, which may be unsubstituted or substituted by one, two or three substituents being independently selected from a group consisting of F, Cl, Br, NO2, CF3, CH3, C2H5, OCH3, OC2H5, CF3, NMe2, NEt2, SCH3, and NHCOCH3,
- wherein general formula VI is denoted by formula II where R2=CHO;
- general formula VI is denoted by formula IV where R2=—CH═CHCOR4 and general formula VI is denoted by formula VII where X=NR3 and R2=—CH═CHCOR4.
A compound of general formula (III) or a pharmaceutically acceptable salt thereof
- wherein:
- R is selected from the group consisting of:
- H, CHO, COCH3, NHCOCH3, F, Cl, Br, NO2, CF3, OCF3, CH3, C2H5, C3H7, straight or branched alkyl chain up to six carbons, straight or branched alkoxy/sulphoxy chain up to six carbons, unsubstituted or substituted phenyl ring, wherein the substituents in phenyl ring is selected from a group consisting of F, Cl, Br, NO2, CF3, CH3, C2H5, OCH3, OC2H5, and OCF3, R2, R3, R4 which may be unsubstituted or substituted by one, two or three substituent's being independently selected from the group of consisting of F, Cl, Br, NO2, CF3, CH3, C2H5, OCH3, OC2H5, CF3, NMe2, NEt2, SCH3, and NHCOCH3.
A pharmaceutical composition comprising of the general formula (III) and/or (VI) as defined in preceding claims, in combination with one or more pharmaceutically acceptable salts optionally along with pharmaceutically acceptable excipients, diluents, binders, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof.
Dependencies are inferred from the claim text.