Selective Ablation of Pain-Sensing Neurons by Administration of a Vanilloid Receptor Agonist
AssigneeThe Gov. of the U.S.A. as Represented by the Secretary of the Dept. of Health and Human Service
InventorsMichael J. Iadarola, Zoltan Olah, Laszlo Karai
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Abstract
The present invention provides methods and kits for the selective ablation of pain-sensing neurons. The methods comprise administration of a vanilloid receptor agonist to a ganglion in an amount that causes death of vanilloid receptor-bearing neurons. Accordingly, the present invention provides methods of controlling pain and inflammatory disorders that involve activation of vanilloid receptor-bearing neurons.
Claims23
A method of treating pain in a patient comprising administering a vanilloid receptor-1 (VR1) agonist to the patient, wherein the VR1 agonist is administered to a ganglion.
A kit for injecting a VR-1 agonist into a ganglion, the kit comprising the VR-1 agonist and a local anesthetic.
Dependencies are inferred from the claim text.