Aptamers to glycoprotein vi
AssigneeDuke University
InventorsBruce A. Sullenger, Kristin M. Bompiani
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Abstract
The present invention relates, in general, to glycoprotein VI (GPVI) and, in particular, to aptamers to GPVI and to compositions comprising same. The invention also relates to methods of inhibiting platelet aggregation using an aptamer that binds to and inhibits the activity of GPVI. The invention further relates to antidotes to GPVI aptamers and to methods of using such antidotes to reverse aptamer-induced platelet inhibition. The invention also relates to aptamers that bind to and enhance the activity of GPVI.
Claims15
An aptamer that binds to and inhibits the activity of GPVI.
An aptamer that binds to and enhances the function or activity of GPVI.
An aptamer having a sequence selected from group of sequences set forth in SEQ ID NOs:1-45.
Dependencies are inferred from the claim text.