Method and Therapeutic for the Treatment and Regulation of Memory Formation
AssigneeThe Regents of the University of California
InventorMarcelo Andres Wood
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Abstract
A methodology and pharmaceutical and gene therapies for the treatment and regulation of memory function are provided. The invention identifies specific HDAC, and in particular, HDAC3 and HDAC4 as negative regulators of memory formation and specifically targets one or both HDAC3 and HDAC4 for down-regulation. By specifically targeting HDAC3 and HDAC4 with small molecule inhibitors and gene therapies it is possible to provide a powerful therapeutic approach to facilitate gene expression during memory formation that can lead to the regulation and treatment of memory disorders.
Claims36
A method of regulating the transcription required for long-term memory formation for treating a memory disorder comprising:
- administering a therapeutic amount of a pharmaceutical that selectively down-regulates the functional activity of at least one of HDAC3 and HDAC4 to a patient diagnosed with the memory disorder.
A pharmaceutical compound for the treatment of a memory disorder comprising:
- a therapeutically effective amount of at least one medicament that selectively down-regulates the functional activity of at least one of HDAC3 and HDAC4.
A method of regulating the transcription required for long-term memory formation for treating a memory disorder comprising:
- inserting a point mutation by a gene therapy technique to disrupt the NCoR/HDAC3/HDAC4 complex to selectively down-regulate the functional activity of at least one of HDAC3 and HDAC4 in a patient diagnosed with the memory disorder.
Dependencies are inferred from the claim text.