Cancer therapy
AssigneeBrandeis University
InventorsRuibao Ren, Benjamin Cuiffo
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Abstract
The present invention provides agents useful in the treatment of cancer, as well as systems for identifying and/or characterizing such agents, and systems for identifying and/or characterizing patient populations responsive to particular agents.
Claims11
A method of treating cancer by administering to a patient in need thereof an agent that inhibits palmitoylation of NRAS.
A method of identifying agents useful in the treatment of cancer, the method comprising steps of:
- providing one or more agents that inhibit RAS palmitoylation;
- and
- assessing ability of the agents to inhibit proliferation of cancer cells.
A method of treating cancers associated with activated RAS that requires palmitoylation, the method comprising steps of:
- administering a FASN inhibitor to a subject suffering from a cancer that is associated with activated RAS requiring palmitoylation.
A method for treating cancer comprising:
- administering a FASN inhibitor and a RAS palmitoylation inhibitor in combination.
A method comprising steps of:
- identifying in a cancer patient suffering from or susceptible to a cancer associated with an activated RAS that requires palmitoylation;
- determining, based on the identification, that the patient is a good candidate for therapy with a FASN inhibitor and/or a RAS palmitoylation inhibitor.
Dependencies are inferred from the claim text.