Composition and method for inner ear sensory hair cell regeneration and replacement
AssigneeHough Ear Institute
InventorRichard D. Kopke
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Abstract
A composition and method for replacement and regeneration of hair cells of the inner ear is provided. The composition comprises an active agent in an amount effective to decrease Hes1 gene expression in a tissue of the inner ear. The active agent can be short interfering RNA (siRNA) molecules encapsulated in a biodegradable nanoparticle. The method involves administering a solution to the inner ear where the solution contains an active agent in an amount effective to decrease Hes1 gene expression.
Claims21
1-45. (canceled)
A composition for regenerating hair cells of the inner ear comprising:
- a nanoparticle formed of a biodegradable polymer, the nanoparticle comprising a siRNA molecule sufficient to decrease the expression of Hes 1, wherein the siRNA molecule is in an amount effective to regenerate hair cells of the inner ear.
A method for regenerating hair cells of the inner ear comprising:
- applying a composition to the inner ear of an organism in an amount effective to regenerate hair cells of the inner ear, wherein the composition comprises a nanoparticle formed of a biodegradable polymer, the nanoparticle comprising a siRNA molecule sufficient to decrease the expression of Hes 1.
Dependencies are inferred from the claim text.